Nattokinase is a powerful enzyme used to support normal blood flow, circulation, and blood pressure levels. Maintaining healthy blood circulation and balanced coagulation is a key part of supporting cardiovascular health. Fibrinolytic enzymes, such as plasmin, produced in the endothelial cells are responsible for ensuring proper blood flow. However, production of these enzymes decreases with age, which can result in increased fibrin levels. In vitro studies have highlighted that nattokinase triggers the release of substances that lead to production of other important enzymes, like plasmin, which help regulate fibrin formation. Nattokinase also inhibits a key enzyme which causes arterial dilation to help maintain healthy blood pressure levels, and can generate tissue plasminogen activators helping to promote blood flow.